Biodegradable Materials for Drugs Delivery Applications for Social Benefit of Mankind

Abstract

Biodegradable and non-toxic poly[bis(p-oxy azo benzoic acid diethylamino) phosphazenes] (POABADEAP) was synthesized in two steps. In first step, the polydichlorophosphazenes (PDCP) was synthesized from hexachlorocyclotriphosphazene (HCCP) by thermal ring opening polymerization in the presence of AlCl3 as catalyst and in second step chlorines from PDCP were substituted by hydroxy groups of p-hydroxy azobenzoic acid and then diethylamine respectively. The synthesis results were proved by 1H NMR and GPC. Hydrolytic degradation of POABADEAP was studies and it was found that polymer degraded smoothly for the biomedical application such as drugs delivery and for social benefits of human beings.